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Welcome to the Medical Science Review

Medical Science Review (MSR) has developed as an independent title in 2014 as a continuation of highly successful Review Section of the Medical Science Monitor (since 1995). The aim of the Journal is to gather review articles across all medical disciplines, thereby integrating international medical knowledge. Medical Science Review has adopted the Open Access publishing model which enables free access... read more


Published: 2016-12-20

Use of Somatic Mutation Detection Methods in Cancer

Yang Yang, Tingting Qu, Shuqin Jia

(Laboratory of Surgery, The Affiliated Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China (mainland))

Med Sci Rev 2016; 3:119-126

DOI: 10.12659/MSRev.902012


ABSTRACT: Somatic mutation theory states that somatic mutation is probably associated with the nature of cancer, which emphasizes the importance of somatic mutation in cancer occurrence. In recent years, several new detection techniques have been widely utilized to explore the somatic mutation, and this accumulated evidence has increasingly clarified the role of somatic mutation in mediating cancer occurrence. Here, we summarize several common techniques used for the detection of somatic mutations, including Direct Sequencing, Next-Generation Sequencing, PCR-SSCP, MRD, and MLPA. The practical applications of these detection methods in diverse cancer types were also introduced to further analyze both the advantages and the defects of each detection method in different types of mutation detection, which not only reveals the significance of somatic mutation detection methods in cancer prediction, diagnosis, and treatment, but also provides more suggestions for future research in these related fields.

Keywords: Early Detection of Cancer, genetic therapy, Technology




Published: 2016-09-06

Audiogenic Seizures and Their Importance in Experimental Behavioral Studies: A Review


Ipek Komsuoglu Celikyurt, Esra Isık, Cem Onur Erdolu

Med Sci Rev 2016; 3:110-118

DOI: 10.12659/MSRev.899608

Published: 2016-07-22

Increasing Men’s Interest in Family Planning Centers: Lessons Learned From Switzerland


Leila Sadeghi, Rainer Kamber, Christine Sieber, Francesca Rotunno, Ans Luyben

Med Sci Rev 2016; 3:100-109

DOI: 10.12659/MSRev.898874