ISSN 2373-2490

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Medical Science Review (MSR) has developed as an independent title in 2014 as a continuation of highly successful Review Section of the Medical Science Monitor (since 1995). The aim of the Journal is to gather review articles across all medical disciplines, thereby integrating international medical knowledge. Medical Science Review has adopted the Open Access publishing model which enables free access... read more


Published: 2018-09-04

Role of the Wnt/b-Catenin Pathway Inhibitor Sclerostin in Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)

Chao Zheng, Huang Ding, Linjun Qin, Ali Xiong, Jiulong Wang, Changqing Yin

(Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland))

Med Sci Rev 2018; 5:19-24

DOI: 10.12659/MSRev.911671


ABSTRACT: Sclerostin, an osteocyte-derived biomarker that regulates bone health via inhibition of the Wnt/β-catenin pathway has been widely researched in adynamic bone disease. In recent years, accumulated evidence demonstrates that there exists a dramatic change in sclerostin levels in chronic kidney disease-mineral and bone disorder (CKD-MBD) patients. Also, more investigations have been performed to assess its potential significance in patients with CKD-MBD, which mainly is a systemic disorder of mineral and bone metabolism. This review summarizes the emerging understanding of sclerostin and its role in different pathological and physiological changes of CKD according to 3 aspects – bone metabolism, vascular calcification, and mineral and electrolyte disorder – to discuss and predict its value in clinical settings.

Keywords: Bone Demineralization Technique, Renal Insufficiency, Chronic, renal osteodystrophy




Published: 2018-08-07

Fatal Hemorrhage from Infarction After Deep Brain Stimulation Surgery


Huang Hui, Hu Shangwei, Xie Liyuan, Xiao Bing, Huang Hongming, Guo Ming, Zheng Suyue, Lu Mingwei

Med Sci Rev 2018; 5:14-18

DOI: 10.12659/MSRev.910334

Published: 2018-04-10

Properties of Olfactory Ensheathing Cells Conditioned Medium and Its Potential Therapeutic Effect on Spin...


Zhengchao Gao, Yingjie Zhao, Yiqun Wang, Jiantao Liu, Binbin Niu, Hui Song, Su’e Chang, Haopeng Li, Xijing He

Med Sci Rev 2018; 5:1-13

DOI: 10.12659/MSRev.909751